Table 1.

Treatment plan showing group of hamsters treated with unmodified (Set 1) and SLN-modified nanoparticle (Set 2) forms of chemopreventive agents aspirin, curcumin, and sulforaphane at various doses

GroupTreatment planDose, mg/kg
Set 1
 T1Saline controlSaline (control)0
 T2BOP ControlBOP35 (1st wk)/20 (next 4 wks)
 T3Low-dose ACSASP+CUR+SFN20 + 45 + 1.6
 T4Medium-dose ACSASP+CUR+SFN70 + 150 + 5
 T5High-dose ACSASP+CUR+SFN200 + 450 + 16
Set 2
 T6Saline controlSaline (control)0
 T7Blank SLN controlBlank SLN (vehicle control)0
 T8BOP ControlBOP35 (1st wk)/20 (next 4 wks)
 T9Low-dose SLN ACSASP+CUR+SFN2 + 4.5 + 0.16
 T10Medium-dose SLN ACSASP+CUR+SFN7 + 15 + 0.5
 T11High-dose SLN ACSASP+CUR+SFN20 + 45 + 1.6

Abbreviations: ASP, aspirin; CUR, curcumin; SFN, sulforaphane.