Table 1.

Significant functional annotation of DEG pathways altered by vorozole treatment

GOTERM, KEGG pathways gene set pathways modulated by vorozole
Pathway termsPathway descriptionsGenes with altered expression% Of genes in pathway with altered expressionP
Downregulated by vorozole treatment
 GOTERM_BP_3Cell-cycle process1314.19.10E−08
 GOTERM_BP_3Cell-cycle phase11121.30E−07
 GOTERM_BP_3Organelle fission77.61.20E−05
 GOTERM_BP_3Gas transport44.38.10E−05
 GOTERM_BP_3Mitotic cell cycle88.79.40E−05
 GOTERM_BP_3Positive regulation of cell cycle55.41.00E−04
 KEGG_PATHWAYCell cycle77.61.50E−05
Upregulated by vorozole treatment
 GOTERM_BP_3Cell chemotaxis74.61.50E−06
 GOTERM_BP_3Taxis85.21.10E−05
 GOTERM_BP_3Homeostatic process2013.12.40E−05
 GOTERM_BP_3Cell migration127.82.50E−05
 GOTERM_BP_3Response to drug138.54.40E−05
Gene set pathways
 ZHAN_MM_CD138_PR_VS_RESTProliferation genes myeloma18750.006
 CROONQUIST_IL6_RAS_DNDownregulated myeloma by IL-613720.002
 REN_E2F1_TARGETSE2F1 targets in WI-38 fibroblast15540.004
 CMV_IE86_UPUpregulated by CMV EI86 protein in fibroblasts18470.012
 P21_P53_MIDDLE_DNDownregulated in OvCA cells by p2113760
 YU_CMYC_UPC-Myc activated genes15540.008