Table 2.

Genes altered by treatment with aromatase inhibitor in both rat model and human ER+ breast cancer

RatHuman
E-TABM-180GSE10281GSE16391GSE5462
Gene symbolGene accessionFCPFCPFCPZ valuePFCP
AspmNM_001105955−1.390.020−3.061.1E−04−2.420.017−2.36<1E−07
AurkaNM_153296−1.390.031−2.350.002−2.250.024−1.661.8E−07
Bard1NM_022622−1.370.004−1.542.96E−02−1.537.85E−04−1.651.5E−04
Bub1NM_001106507−2.110.007−2.391.8E−04−2.610.011−1.53<1E−07
Bub1bENSRNOT00000010406−1.630.002−2.762.3E−05−2.150.032−1.55<1E−07
Ccna2NM_053702−1.800.003−2.430.002−2.410.017−1.55<1E−07
Ccnb1NM_171991−1.720.008−2.381.3E−04−2.260.024−1.67<1E−07
Ccne2NM_001108656−1.380.026−1.680.008−2.270.024−1.58<1E−07
Cdc2NM_019296−1.930.003−1.531.00E−02−2.530.004−2.570.011−1.801.3E−07
CenpfENSRNOT00000004525−2.170.001−2.641.7E−05−2.630.009−1.69<1E−07
Cep55NM_001025646−1.350.042−2.537.3E−04−2.000.045−1.986.7E−07
DtlENSRNOT00000005576−1.360.036−1.562.64E−03−2.422.2E−04−2.090.038
E2f8ENSRNOT00000035512−1.360.001−1.532.78E−05−2.350.003−2.270.023
Ect2NM_001108547−1.860.003−1.830.001−2.080.038−1.541.6E−07
Espl1ENSRNOT00000017314−1.160.010−1.656.2E−04−1.980.047−1.72<1E−07
Gins1NM_001109207−1.570.008−2.120.001−2.480.013−1.593.9E−07
HmmrNM_012964−1.890.008−2.123.0E−04−2.220.027−1.72<1E−07
Kif20aNM_001108426−1.350.016−3.051.8E−04−2.390.017−1.95<1E−07
MelkNM_001108662−1.500.001−1.503.82E−04−3.069.1E−05−2.720.007−1.82<1E−07
Mki67ENSRNOT00000038176−2.060.005−1.621.16E−02−2.165.5E−05−2.210.028
Ns5atp9NM_201418−1.510.129−1.617.82E−07−2.306.3E−05−2.320.021−1.78<1E−07
PbkNM_001079937−2.430.002−3.262.9E−05−2.210.027−1.73<1E−07
Prc1NM_001107529−1.760.001−1.641.83E−03−2.931.0E−05−2.000.046−1.94<1E−07
Top2aNM_022183−2.550.001−1.649.55E−05−3.324.0E−06−2.470.014−2.483.5E−06
TtkNM_001108172−1.840.002−2.450.004−2.090.036−1.74<1E−07
TymsNM_019179−1.420.035−2.126.1E−05−2.670.008−1.51<1E−07
Arid5bNM_0011076241.370.0581.651.57E−081.504.6E−041.990.047
DcnNM_0241291.560.0252.251.85E−031.895.3E−051.651.8E−04
FosNM_0221971.240.0311.782.82E−033.400.0142.710.007
Ms4a6bNM_0010069751.930.0081.797.30E−051.510.0052.180.031
PtprcNM_0011098901.590.0782.341.72E−081.920.0162.460.014
TfNM_0010131102.510.0061.621.87E−031.730.0202.260.024