Table 2.

Changes in serum fatty acids and eicosanoids

Western diet postintervention minus preinterventionLFFO postintervention minus preintervention
Fatty acidsa(n = 21; mean ± SEM)(n = 27; mean ± SEM)P value
Palmitic−0.8 ± 0.46−0.62 ± 0.320.7
Palmitoleic−0.45 ± 0.22−0.28 ± 0.10.9
Stearic−0.14 ± 0.08−0.42 ± 0.130.2
Oleic−1.17 ± 0.63−2.35 ± 0.430.2
Linoleic acid (n-6)2.4 ± 0.93−1.68 ± 0.63<0.01
α-Linolenic (n-3)0.03 ± 0.040.009 ± 0.050.9
Eicosadienoic (n-6)−0.005 ± 0.009−0.009 ± 0.0090.6
Arachidonic acid (20:4, n-6)0.48 ± 0.27−0.75 ± 0.21<0.01
EPA (20:5, n-3)−0.23 ± 0.051.97 ± 0.14<0.01
Docosapentaenoic (n-3)0.007 ± 0.020.16 ± 0.03<0.01
DHA (22:6, n-3)−0.12 ± 0.083.98 ± 0.19<0.01
Total n-62.88 ± 1.12−2.44 ± 0.67<0.01
Total n-3−0.32 ± 0.136.12 ± 0.3<0.01
n-6/n-31.41 ± 0.42−5.76 ± 0.42<0.01
% Change from baseline% Change from baseline
Eicosanoidsb(n = 21; mean ± SEM)(n = 27; mean ± SEM)P value
15(S)-HETE24.7 ± 11.4−7.2 ± 6.60.02
LTB4−9.7 ± 7.4−14.9 ± 5.60.6
  • aChanges in serum fatty acids are expressed as postintervention minus preintervention.

  • bEicosanoid changes were calculated for each patient as percentage of change from baseline.