Table 1.

Clinical features and SNP array results of 18 patients

Histology gradeSample nameBronchial locationBiopsy/brushPatient numberSCA detectionSmoking historyHistology stability
SQIC-1LULBrush1YesFormer
SQIC-2RLLBrush1YesFormer
SQIC-3RULBrush1YesFormer
SQIC-4RULBrush2YesCurrent
SQIC-5RULBiopsy3YesCurrent
LCIC-6LUDBBiopsy4YesCurrent
CISCIS-1LULBiopsy5YesCurrentPersistent
CISCIS-2LUDBBiopsy6YesCurrentPersistent
CISCIS-3LULBrush7YesCurrentPersistent
SDSD-1RMLBiopsy5YesCurrent
SDSD-2LLLBrush8NoFormer
SDSD-3RULBrush9NoCurrentRegressive
SDSD-4RULBrush10NoFormer
MDMD-1LULBrush6YesCurrentPersistent
MDMD-2RULBrush6NoCurrent
MDMD-3LUL(Li)Brush7YesCurrentPersistent
MDMD-4RLLBrush7NoCurrent
MDMD-5RULBrush11NoCurrentRegressive
MDMD-6LULBrush12NoFormerPersistent
MDMD-7RMLBrush12NoFormerRegressive
MiDMiD-1LULBrush12NoFormerPersistent
MiDMiD-2LUDBBrush13NoCurrent
MiDMiD-3RULBrush14NoCurrentRegressive
MiDMiD-4RMLBrush15NoFormerRegressive
HPHP-1RLLBiopsy5NoCurrent
HPHP-2LULBrush16NoCurrent
HPHP-3RULBrush15NoFormerPersistent
NHNH-1RMLBrush11NoCurrent
NHNH-2LUDBBrush17NoFormerPersistent
NHNH-3RMLBrush18NoFormerPersistent

NOTE: The results of Fisher exact tests in arrayed patients/lesions with 5–7 histology grade; P = 0.20 in current versus former smokers with SCA detection compared with no SCA detection, and P = 0.048 in persistence versus regression of lesions with SCA detection compared with no SCA detection. Disease stability: persistent change, ≤ 1 histology grade; regressive change, ≥ 2 grades; and —, no repeated bronchoscopy available.

Abbreviations: HP, hyperplasia; LC, large cell lung cancer; LUL, left upper lung; LUDB, left upper divisional bronchus; LUL(Li), left upper lung (lingula); LLL, left lower lung; MiD, mild dysplasia; MD, moderate dysplasia; NH, normal histology; RLL, right lower lung; RML, right middle lung; RUL, right upper lung; SD, severe dysplasia; SQ, squamous cell lung cancer.