Table 1.

MAPcL candidates for generation of rFc fusion proteins

Gene from MAPcLAccession No.Signal sequencea amino acidsEncoded amino acid fragmentb
ANGPTL4NM_1393141–3031–406
CD147NM_1985891–2122–162
CD320NM_0165791–4647–230
CDH3NM_0017931–2425–654
CST2NM_0013221–2021–141
DKK1NM_0122421–2829–266
EPHA2NM_0044311–2627–535
GAL1NM_0023051–1718–135
GFRA1AF0384211–2425–465
GRNNM_0020871–1718–593
HER-2NM_0044481–2223–652
IGFBP2NM_0005971–3940–328
LAMC2NM_0055621–2122–1111
LRP10NM_0140451–1617–440
LRRC15NM_0011350571–2728–544
MUC1NM_0024561–2223–167
SPINT2NM_0211021–2728–198
SPON2NM_0124451–2627–331
SSR2NM_0031451–1718–146
SUSD2NM_0196011–2728–785
  • aThe signal sequences of each encoded protein were determined using SignalP (32, 33) and were not included in the expression constructs.

  • bThe amino acid numbers indicate the encoded portion of the proteins cloned between the IgG signal sequence and the Fc portion of rabbit IgG to generate the secreted MAPcL–rFc fusion proteins.