Table 3.

Association of non–Alu-gene overmethylation with the risk of gastric cancer stratified by the extent of gastric atrophy

Number of cases with non–Alu-gene overmethylationa
Gastric cancerAll noncancer controlsOR (95% CI)bH. pylori–positive controlsOR (95% CI)b
Antrum
Total cases80/102 (78)78/226 (35)5.5 (3.1–9.6)43/114 (38)4.7 (2.5–8.8)
 No atrophic change0/03/19 (16)0/4 (0)
 Closed type46/57 (81)60/176 (34)7.3 (3.4–15.5)31/91 (34)7.2 (3.1–16.8)
  C14/5 (80)7/24 (29)5.7 (0.3–94.0)2/10 (20)5.7 (0.3–109.3)
  C219/24 (79)24/82 (29)10.2 (3.1–33.7)13/44 (30)9.7 (2.4–39.7)
  C323/28 (82)29/70 (41)6.2 (2.1–18.5)16/37 (43)6.3 (1.9–21.2)
 Open type34/45 (76)15/31 (48)3.4 (1.2–9.3)12/19 (63)1.8 (0.5–5.9)
Body
Total cases61/102 (60)89/226 (39)1.9 (1.1–3.1)38/114 (33)2.5 (1.4–4.5)
 No atrophic change0/06/19 (32)0/4 (0)
 Closed type32/57 (56)64/176 (36)2.0 (1.1–3.8)29/91 (32)2.4 (1.2–5.1)
 Open type29/45 (64)19/31 (61)1.1 (0.4–2.9)9/19 (47)2.0 (0.6–5.9)

NOTE: Data are n/N (%) unless otherwise stated.

  • aNon–Alu-gene overmethylation was scored (i) if at least 1 LTR-adjacent gene and at least 1 stomach-specific gene were overmethylated and (ii) if the number of overmethylated Alu-adjacent genes was fewer than that of overmethylated LTR-adjacent genes.

  • bAdjusted for age and sex.