Table 2.

Logistic regression analysis of potential adenoma recurrence–related factors

Univariate analysisMultivariate analysis
CharacteristicOR (95% CI)POR (95% CI)P
Two cohorts combined (excluding 37 healthy volunteers and 11 withdrawn patients, n = 374)
Age at enrollment, y
 <601.0 (reference)
 ≥601.18 (0.79–1.79)0.434
Gender
 Female1.0 (reference)
 Male1.53 (0.98–2.39)0.0631.29 (0.74–2.26)0.375
BMI
 <231.0 (reference)
 ≥230.95 (0.63–1.44)0.808
FFPE-based miR-194 expression
High (log10 (2−ΔCt)>0.1311)1.0 (reference)
Low (log10 (2−ΔCt)≤0.1311)8.89 (5.52–14.32)<0.0018.51 (4.88–14.83)<0.001
Adenoma sizea
 <1 cm1.0 (Reference)
 1 to 2 cm1.15 (0.70–1.91)0.5741.07 (0.60–1.92)0.816
 ≥2 cm3.18 (1.41–7.17)0.0053.04 (1.13–8.20)0.028
No. of adenomas
 <31.0 (reference)
 ≥32.50 (1.59–3.92)<0.0012.14 (1.23–3.74)0.007
Location
 Distal colon and rectum1.0 (reference)
 Bothb1.54 (0.97–2.45)0.0700.84 (0.46–1.54)0.580
 Proximal2.82 (1.44–5.50)0.0021.00 (0.44–2.24)0.991
Villous componentsc
 <50%1.0 (reference)
 ≥50%1.70 (1.12–2.60)0.0121.14 (0.66–1.97)0.645
Intraepithelial neoplasia
 Mild grade1.0 (reference)
 High grade1.82 (1.15–2.88)0.0111.75 (0.98–3.15)0.061
  • aSize of largest adenoma.

  • bAdenomas in both distal colon and rectum and proximal colon.

  • cHighest degree of histology.