Table 1.

Drug concentrations of veliparib and olaparib in BRCACo/Co;MMTV-Cre;p53+/− mice

VeliparibOlaparib
(100 mg/kg diet)(200 mg/kg diet)
Plasma, nmol/L96 ± 1236 ± 11
Mammary gland, nmol/kg of body weight96 ± 1516 ± 3
Liver, nmol/kg of body weight437 ± 123636 ± 264

NOTE: Plasma, mammary gland, and liver from mice fed with 100 mg/kg of veliparib or 200 mg/kg of olaparib diet for 2 weeks were harvested. Tissue concentrations of the PARP inhibitors were measured by LC/MS; n = 3 mice per group.