Table 6.

Effect of genotype at rs11781866 and rs2228013 on high-grade prostate cancer risk in each arm of the SELECT case–control cohort

Intervention arm
PlaceboVitamin ESeleniumVitamin E + selenium
Genotype
High-grade casesHR (95% CI)PHR (95% CI)PHR (95% CI)PHR (95% CI)P
All genotypes1.00 (Ref)Ref1.250 (0.942–1.658)0.12241.201 (0.902–1.598)0.20991.212 (0.911–1.612)0.1868
rs11781886
 TT1.000 (Ref)Ref1.015 (0.672–1.533)0.94471.059 (0.710–1.579)0.77961.297 (0.871–1.931)0.2002
 CT1.027 (0.656–1.609)0.90581.753 (1.146–2.680)0.00961.308 (0.839–2.039)0.23551.078 (0.692–1.678)0.7401
 CC1.164 (0.519–2.611)0.71231.131 (0.515–2.484)0.76001.325 (0.559–3.140)0.52241.079 (0.435–2.676)0.8695
Ptrend0.75860.35960.64330.4247
rs2228013
 GG1.000 (Ref)Ref1.209 (0.896–1.630)0.21381.173 (0.869–1.584)0.29691.197 (0.887–1.616)0.2407
 AG or AA0.909 (0.444–1.862)0.79381.223 (0.635–2.354)0.54721.240 (0.593–2.589)0.56770.928 (0.448–1.922)0.8413
Ptrend0.79380.82780.77240.7592