Table 4.

Effect of genotype at rs11781886 and rs2228013 on total prostate cancer risk in each intervention arm of the SELECT case–control cohort

Intervention arm
PlaceboVitamin ESeleniumVitamin E + selenium
N = 1,220N = 1,318N = 1,247N = 1,216
Genotype rs11781886HR (95% CI)PHR (95% CI)PHR (95% CI)PHR (95% CI)P
All genotypes1.000 (Ref)Ref1.178 (0.987–1.405)0.06881.091 (0.913–1.304)0.33671.021 (0.853–1.222)0.8171
 TT1.000 (Ref)Ref1.142 (0.891–1.463)0.29511.074 (0.836–1.379)0.57531.218 (0.947–1.567)0.1238
 CT1.175 (0.895–1.542)0.24481.500 (1.124–1.971)0.00361.218 (0.918–1.617)0.17100.966 (0.733–1.272)0.8048
 CC1.144 (0.690–1.898)0.60151.233 (0.744–2.042)0.41621.676 (1.011–2.777)0.04500.987 (0.541–1.803)0.9671
Ptrend0.28970.85480.64570.0634
rs2228013
 GG1.000 (Ref)Ref1.165 (0.968–1.403)0.10661.064 (0.882–1.283)0.51911.037 (0.859–1.252)0.7074
 AG or AA0.912 (0.574–1.447)0.69521.137 (0.742–1.740)0.55571.365 (0.876–2.128)0.16850.740 (0.456–1.203)0.2247
Ptrend0.69520.83300.29340.4722