Table 5.

Effect of genotype at rs11781866 and rs2228013 on low-grade prostate cancer risk in each arm of the SELECT case–control cohort

Intervention arm
PlaceboVitamin ESeleniumVitamin E + selenium
Genotype
Low-grade casesHR (95% CI)PHR (95% CI)PHR (95% CI)PHR (95% CI)P
All genotypes1.00 (ref)Ref1.070 (0.867–1.319)0.52941.004 (0.812–1.241)0.97280.932 (0.752–1.154)0.5166
rs11781886
 TT1.000 (ref)Ref1.159 (0.864–1.554)0.32511.018 (0.754–1.375)0.90541.182 (0.874–1.599)0.2764
 CT1.261 (0.917–1.734)0.15371.267 (0.910–1.765)0.16081.172 (0.836–1.643)0.35600.915 (0.658–1.273)0.5977
 CC1.160 (0.649–2.074)0.61561.341 (0.742–2.424)0.33121.811 (1.016–3.228)0.04411.010 (0.487–2.095)0.9795
Ptrend0.22120.70160.64880.0802
rs2228013
 GG1.000 (ref)Ref1.079 (0.865–1.346)0.49970.987 (0.789–1.235)0.90820.956 (0.764–1.197)0.6968
 AG or AA0.974 (0.568–1.670)0.92321.036 (0.621–1.728)0.89151.386 (0.833–2.308)0.20910.761 (0.431–1.343)0.3461
Ptrend0.92320.97050.33170.6115