Table 3.

Diagnostic performance of the FIT and BLF methylation test for detection of colorectal cancer

FIT only
StudyTotal NCRCCRC-freeSensitivitySpecificityPPVNPV
Allison et al.7,493327,4610.6880.9440.0500.999
Current study349173320.8240.4280.0900.984
FIT and BLF methylation test
FIT-negative group
M-scoreTotal NCRCCRC-freeCutoffSensitivitySpecificityPPVNPVP
01020102
154054≥11.0000.5370.0001.0000.103
225124≥21.0000.8210.0811.0000.007
31221030.6670.9470.1670.9940.090
FIT-positive group
M-scoreTotal NCRCCRC-freeCutoffSensitivitySpecificityPPVNPVP
082280
143538≥10.8570.5630.1620.9760.004
21257≥20.5000.8310.2260.9440.008
31921730.1430.8800.1050.9120.681

NOTE: P value were calculated using the Fisher exact test.

Abbreviations: CRC, colorectal cancer; NPV, negative predictive value.