Table 2.

Baseline characteristics of SELECT case–control cohort (N = 5,001)

Non-cases, n (%)Cases, n (%)High-grade cases, n (%)Low-grade cases, n (%)
CharacteristicN = 3,135N = 1,866N = 540N = 1,081
Age, y
 <55126 (4.0%)42 (2.3%)11 (2.0%)22 (2.0%)
 55–59832 (26.5%)503 (27.0%)123 (22.8%)311 (28.8%)
 60–64926 (29.5%)565 (30.3%)150 (27.8%)339 (31.4%)
 65–69724 (23.1%)437 (23.4%)138 (25.6%)242 (22.4%)
 ≥70527 (16.8%)319 (17.1%)118 (21.9%)167 (15.4%)
Race
 White (non-Hispanic)2,175 (69.4%)1,521 (81.5%)439 (81.3%)899 (83.2%)
 African American756 (24.1%)253 (13.6%)79 (14.6%)130 (12.0%)
 Other204 (6.5%)92 (4.9%)22 (4.1%)52 (4.8%)
Body mass index, kg/m2
 <25606 (19.3%)357 (19.1%)98 (18.1%)207 (19.1%)
 25–<301,466 (46.8%)950 (50.9%)244 (45.2%)583 (53.9%)
 ≥301,052 (33.6%)556 (29.8%)197 (36.5%)289 (26.7%)
 Unknown11 (0.4%)3 (0.2%)1 (0.2%)2 (0.2%)
Smoking status
 Never1,292 (41.2%)894 (47.9%)263 (48.7%)516 (47.7%)
 Former1,553 (49.5%)868 (46.5%)246 (45.6%)500 (46.3%)
 Current267 (8.5%)99 (5.3%)28 (5.2%)63 (5.8%)
 Unknown23 (0.7%)5 (0.3%)3 (0.6%)2 (0.2%)
Baseline PSA
 0.00–0.991,391 (44.4%)134 (7.2%)33 (6.1%)73 (6.8%)
 1.00–1.991,070 (34.1%)486 (26.0%)140 (25.9%)269 (24.9%)
 2.00–2.99444 (14.2%)627 (33.6%)196 (36.3%)360 (33.3%)
 ≥3230 (7.3%)618 (33.1%)171 (31.7%)378 (35.0%)
 Unknown0 (0.0%)1 (0.1%)0 (0.0%)1 (0.1%)
History of diabetes
 No2,737 (87.3%)1,733 (92.9%)491 (90.9%)1,018 (94.2%)
 Yes398 (12.7%)133 (7.1%)49 (9.1%)63 (5.8%)
First-degree relative with prostate cancer
 None2,626 (83.8%)1,284 (68.8%)384 (71.1%)733 (67.8%)
 ≥1507 (16.2%)582 (31.2%)156 (28.9%)348 (32.2%)
 Unknown2 (0.1%)0 (0.0%)0 (0.0%)0 (0.0%)
SELECT intervention assignment
 Vitamin E + selenium772 (24.6%)448 (24.0%)138 (25.6%)257 (23.8%)
 Vitamin E alone800 (25.5%)518 (27.8%)148 (27.4%)291 (26.9%)
 Selenium alone782 (24.9%)465 (24.9%)138 (25.6%)265 (24.5%)
 Placebo781 (24.9%)435 (23.3%)116 (21.5%)268 (24.8%)
SNP: rs11781886
 TT1,717 (54.8%)984 (52.7%)273 (50.6%)579 (53.6%)
 CT1,184 (37.8%)737 (39.5%)227 (42.0%)411 (38.0%)
 CC211 (6.7%)136 (7.3%)37 (6.9%)86 (8.0%)
 Unknown23 (0.7%)9 (0.5%)3 (0.6%)5 (0.5%)
SNP: rs2228013
 GG2,864 (91.4%)1,693 (90.7%)488 (90.4%)978 (90.5%)
 AG233 (7.4%)150 (8.0%)45 (8.3%)90 (8.3%)
 AA5 (0.2%)2 (0.1%)0 (0.0%)2 (0.2%)
 Unknown33 (1.1%)21 (1.1%)7 (1.3%)11 (1.0%)