Table 2.

Prevention of cancer with natural compounds

CompoundsCancer typeTumor cell linesp53 statusCell-cycle arrestReferences
Flavonoids
 MagnololGlioblastoma, bladder, breast, colon, gastric, skin, ovarian, lung, prostate, melanoma, liver cancer, cervical epitheloid carcinoma, leukemia, fibrosarcoma, neuroblastoma, thyroid carcinomaU373, T24, 5637, MDA-MB-231, HCT- 116, SW480, SGC-7901, A431, SKOV3, TOV21G, CH27, A549, H460, PC-3, A375-S2, B16-BL6, COLO-205, HepG2, HEp-2, HeLa, 2H3, HT-1080, SH-SY5Y, CGTH W-2G0–G1 phase(39, 40, 102, 115, 152–161)
 CasticinCervical, pancreatic, colon, breast, lung, gastric, ovarian, liver, colorectal, leukemiaHeLa, CasKi, SiHa, PANC-1, MCF-7, A549, SGC-7901, HO-8910, SKOV3, HepG2, PLC/PRF/5, MN1, MDD2, MCF-7, A431, HeLa, CCRF-CEM, CEM/ADR5000, P27kip1, P21waf1, pCDC2, K562, HL-60, Kasumi-1Mutant p53G2–M phase(80, 132, 133, 162–165)
 HonokiolGlioblastoma, melanoma, gastric, leukemia, skin, colon, breast, ovarian, pancreatic, hepatocellular, colorectal, lung, prostate, human renal mesangial, head and neck squamous carcinomaA549, H1299, H460, H226, T98G, U251, B16-F10, UACC903, MKN45, SCM-1, NB4, K562, B-CLL, ChR, B-CLL, MT-2, MT-4, C5/MJ, SLB-1, HUT-102, MT-1, TL-OmI, SKH-1, CT26, HT-29, MCF-7, 4T1, MDA-MB -231, SKOV3, Coc1, A2780, Angelen MiaPaCa, Panc1, HepG2, HCT116, CT26, HCT116-CH2, HCT116-CH3, HepG2, A549, LL2, PC-3, LNCaP, HRMCs 1483, Cal-33G2–M phase(38–40, 156, 157, 166–178)
G0–G1 phase
 JaceosidinHuman endometrial, human ovary cancer, glioblastoma, breast, epithelial, cervical, mammary epithelialHec1A, CAOV-3, SKOV-3, U87, MCF10A, SiHa, CaSki, MCF10A-rasG2–M phase(134, 179–181)
Sesquiterpenes
 CostunolideHepatocellular carcinoma, ovarian, breast, bladder, melanoma, leukemia, prostate, human monocyte, gastricHCC, SKOV3, A2780, MPSC1, MPSC1PT, A2780PT, SKOV3PT, MDA-MB-231, MCF-7, MDA-MB-231, T24, B-16, A2058, HT-29, HepG2, HL-60, U937, A549, SK-MEL-2, XF498, HCT-15, LNCaP, PC-3, DU-145, THP-1, SGC-7901Mutant p53 wild-type p53G2–M phase(112, 135, 160, 182–186)
 ParthenolideBreast, skin, melanoma, malignant glioma, epidermal tumorigenesis, liver, gastric, lung, bladder, prostate, bile duct carcinomas, pancreatic, myeloma, leukemia, colorectal, Burkitt lymphoma, epithelial ovarian, osteosarcomaMCF-7, MDMB-231, LCC9, ABCB5+, A375, 1205Lu, WM793, U87MG, U373, JB6P+, SH-J1, HepG2, Hep3B, SK-Hep1, MKN-28, MKN-45, MKN-74, SGC7901, A549, NSCLC, 5637, RT-4, PC3, DU145, VCAP, LAPC4, BxPC-3, PANC-1, MIAPaCa-2, RPMI8226, HL-60, U937, NB4, MV-4-11, MOLM-13, HT-29, SW620, LS174T, Raji+, OVCAR-3, K-OV-3, LM8, LM7G2–M phase(187–201)
 AlantolactoneLiver, glioblastoma, colon, leukemia, lungHepG2, Bel-7402, SMMC-7721, U87, HCT-8, HL-60, K562, K562, ADR, A549, MK-1, HeLa and B16F10G2–M phase(49, 50, 105, 125, 126)
 IsoalantolactoneProstate, pancreatic, leukemia, gastricHepa1c1c7, BPRc1, LNCaP, PC3, DU-145, SGC-7901, HL-60, HepG2-C8, PANC-1G2–M phase(98, 124, 126, 136)
Diterpenoids
 Pseudolaric Acid BMicrovessel endothelial, Prostate, glioblastoma, umbilical vein endothelial, murine fibrosarcoma, bladder, colon, lung, breast, melanoma, ovarian, leukemia, gastric, murine fibrosarcoma, liverDU-145, PC-3, U87, HUVECs, L929, 5637, HT-29, COLO-205, HCT-15, A-549, HOP-18, MCF-7, MDA-MB-231, MALME-3M, SK-MEL-2, SK-28, OVCAR-3, SK-OV-3, HL-60, CCRF-CEM, K562, MGC803, L929, Bel-7402G2–M phase(141, 202–210)
 OridoninBreast, astrocytoma, leukemia, lung, hepatom, prostate, colorectal, pancreatic, ovarian, human multiple myeloma, human histocytic lymphoma, hepatocellular, cervical, neuroblastoma, laryngeal, gastric, murine fibrosarcoma, melanoma, epidermoid carcinoma, osteosarcomaMCF-7, MDA-MB-231, C6, Ph+ ALL SUP-B15, t(8;21), L1210, A549, SPC-A-1, K562, Bel-7402, PC-3, LNCaP, SW480, SW620, SW1116, Lovo, SW480, BxPC-3, PANC-1, A2780, PTX10, RPMI8266, U937, APL, HepG2, BEL7402, HeLa, SK-N-AS, HEp-2, MKN45, L929, K1735M2, A375-S2, A431, U2OS, MG63, SaOS-2G2–M phase(33, 124, 211–228)
Polyphenolic
 WedelolactoneBreast, prostate, neuroblastoma, pancreatic, mammary carcinosarcoma, myeloma, leukemia, adenoma, gliomaMDA-MB-231, MDA-MB-468, PrEC, LNCaP, PC-3, DU145, 22Rv1, SK-N-AS, SK-N-BE, PANC-1, MIA-MSLN, W256, U266, B-CLL, GH3, C6S and G2–M phase(229–237)
Alkaloids
 EvodiamineMurine Lewis lung, hepatocellular, leukemia, gastric, pancreatic, colon, human thyroid cancer, melanoma, colorectal, breast, cervix carcinoma, prostateLLC, HepG2, SMMC-7721, K562, THP-1, CCRF-CEM, CCRF-CEM/C1, U937, SGC-7901, SW1990, ARO, A375-S2, COLO-205, MCF-7, NCI/ADR-RES, HeLa, DU145, PC-3, LNCaPG2–M phase(238–244)