Table 1.

Summary of protein expression and statistical analysis for the individual protein biomarker candidates

Protein nameProtein symbolNCBI numberTime point (days of age)Average expression ratio (Pirc/WT)PSensitivitySpecificityAUCF1–wild-type variance over time
Matrix metalloproteinase-7MMP7NP_036996601.120.46NDNDND25.7%
901.380.0457.1%80.0%0.664
1351.740.00485.7%80.0%0.843
Leucine-rich alpha-2 glycoproteinLRG1NP_001009717601.070.0616.7%100.0%0.67412.9%
901.210.0364.3%90.0%0.857
1351.43<0.00192.9%90.0%0.907
Inter-alpha trypsin inhibitor, heavy chain 4ITIH4NP_062242601.110.0650.0%83.3%0.70115.0%
901.140.0328.6%100.0%0.649
1351.370.00178.6%90.0%0.871
VitronectinVTNNP_062029601.030.618.3%91.7%0.50416.2%
901.120.00135.7%100.0%0.821
1351.200.0271.4%90.0%0.854
HemopexinHPXNP_445770601.150.00650.0%100.0%0.70823.3%
901.26<0.00178.6%100.0%0.882
1351.430.00385.7%80.0%0.792
Epidermal growth factor receptorEGFRNP_113695600.970.338.3%100.0%0.63211.8%
900.870.00250.0%100.0%0.832
1350.65<0.001100.0%80.0%0.939
Coagulation factor VF5NP_001041343601.000.948.3%100.0%0.54511.5%
901.080.0821.4%100.0%0.679
1351.240.00764.3%90.0%0.757
Inter-alpha trypsin inhibitor, heavy chain H3ITIH3NP_059047601.030.5725.0%91.7%0.61516.3%
901.070.0214.3%100.0%0.679
1351.050.3414.3%90.0%0.428
Complement factor ICFINP_077071601.040.5916.7%91.7%0.57623.9%
901.080.2621.4%90.0%0.867
1351.130.2450.0%80.0%0.820
Collagen, type I, alpha 1COL1A1NP_445756601.110.098.3%91.7%0.30957.6%
901.10.117.1%80.0%0.371
1350.910.1842.9%70.0%0.592
Matrix metalloproteinase 10MMP10NP_598198601.020.818.3%83.3%0.46212.0%
901.030.307.1%100.0%0.561
1350.970.480.0%90.0%0.482
CD44 antigenCD44NP_037056601.050.4816.7%75.0%0.28617.8%
901.070.2521.4%90.0%0.755
1350.910.337.1%80.0%0.672

NOTE: MMP7 expression was low in serum and was not identified at the 60-day time point.

Abbreviation: ND, not determined.