Table 1.

Concentrations of eicosanoids in control and EPA + FuOx–treated mouse plasma

EicosanoidControl (FuOx)EPA + FuOx% of Control
6-keto PGF1α48.4 ± 11.720.4 ± 3.842
TXB278.9 ± 54.917.1 ± 0.722
PGE224.0 ± 8.47.7 ± 2.132
13,14-dihydro-15-keto PGE27.9 ± 5.22.2 ± 1.227
Bicyclo PGE221.1 ± 18.05.0 ± 2.824
13,14-dihydro-15-keto PGF2α4.6 ± 2.51.8 ± 0.939
13,14-dihydro-15-keto PGD29.4 ± 6.92.2 ± 1.123
PGJ265.4 ± 33.233.7 ± 17.752
5(6)-EpETrE17.2 ± 9.05.8 ± 1.934
8(9)-EpETrE17.8 ± 9.95.0 ± 1.028
11(12)-EpETrE47.1 ± 22.814.8 ± 3.331
11,12-DiHETrE2.8 ± 1.41.7 ± 0.862
14(15)-EpETrE19.4 ± 16.76.4 ± 1.433
14,15-DiHETrE4.3 ± 2.93.1 ± 1.073
LTB48.4 ± 3.52.0 ± 0.324
12-Oxo LTB44.1 ± 1.40.1 ± 0.13
5-HETE28.7 ± 9.814.9 ± 2.152
5-oxo ETE2.7 ± 0.62.5 ± 0.690
8-HETE33.8 ± 14.29.8 ± 0.529
9-HETE12.2 ± 4.04.4 ± 0.136
11-HETE109.8 ± 49.933.8 ± 6.231
12-HETE1629.0 ± 855.4340.4 ± 144.821
12-Oxo ETE5.1 ± 2.52.0 ± 0.839
15-HETE42.5 ± 20.215.4 ± 1.236
15-Oxo ETE1.1 ± 0.40.7 ± 0.266
8(9)-EpETE2.3 ± 1.51.2 ± 0.453
11(12)-EpETE1.3 ± 1.01.4 ± 0.1110
14(15)-EpETE2.2 ± 1.72.0 ± 0.690
17(18)-EpETE2.9 ± 1.71.6 ± 0.455
5-HEPE4.3 ± 1.73.5 ± 0.680
8-HEPE4.2 ± 1.62.9 ± 0.769
9-HEPE7.2 ± 3.74.0 ± 2.055
11-HEPE5.0 ± 2.33.1 ± 0.461
12-HEPE112.1 ± 67.960.4 ± 40.054
15-HEPE6.4 ± 2.44.0 ± 0.763
18-HEPE3.9 ± 1.43.2 ± 0.680

NOTE: All values are ng/mL plasma (mean ± SEM; n = 3). Metabolites of EPA are italicized.

Abbreviations: DiHETrE, dihydroxyeicosatrienoic acid; EpETrE, epoxyeicosatrienoic acid; EpETE, epoxyeicosatetraenoic acid; ETE, eicosatrienoic acid; HETE, hydroxyeicosatetraenoic acid; HEPE, hydroxyeicosapentaenoic acid; LT, leukotriene; PG, prostaglandin; TX, thromboxane.