Table 1.

Mean plasma concentration-time data and PK estimates

Group 1 (day 1)Group 2 (day 14)
Time (h)Mean plasma concentration (ng/mL; ± SD)Mean plasma concentration (ng/mL; ± SD)
0097 ± 42
17,470 ± 7906,720 ± 390
27,080 ± 1,4904,610 ± 1,090
44,920 ± 1,4105,030 ± 1,240
81,430 ± 5701,470 ± 480
2470 ± 14129 ± 44
PK estimates
Tmax (h)11
Cmax (ng/mL)7,4706,720
Half-life (h)3.74.6
AUC0–24 h (ng/mL × h)47,67044,560