Table 3.

Clinicopathologic characteristics associated with NICD1 IHC staining pattern

NICD1 IHC staining pattern
Positive, peripheralPositive, nonperipheralNegativeTotal
Clinicopathologic characteristicsN (%)N (%)N (%)N (%)P
37 (47)27 (34)15 (19)79 (100)
Age, y0.34
 ≤5518 (55)11 (33)4 (12)33 (42)
 >5519 (41)16 (35)11 (24)46 (58)
Sex0.14
 Male24 (44)22 (41)8 (15)54 (68)
 Female13 (52)5 (20)7 (28)25 (32)
Race0.77
 White31 (46)22 (33)14 (21)67 (88)
 Other5 (56)3 (33)1 (11)9 (12)
Tobacco0.42
 No14 (58)7 (29)3 (12)24 (32)
 Yes22 (42)20 (38)10 (19)52 (68)
Alcohol0.19
 No18 (58)8 (26)5 (16)31 (47)
 Yes13 (47)16 (46)6 (17)35 (53)
Site0.10
 Oropharynx8 (35)12 (52)3 (13)23 (29)
 Other29 (52)15 (27)12 (21)56 (71)
HPV status0.024
 Negative1 (17)2 (33)3 (50)6 (23)
 Positive10 (50)9 (45)1 (5)20 (77)
T Stage0.69
 T1-218 (44)14 (34)9 (22)41 (59)
 T3-T414 (48)11 (38)4 (14)29 (41)
N Stage0.54
 N013 (46)8 (29)7 (25)28 (39)
 N1-N219 (44)17 (40)7 (16)43 (61)
Overall stage0.29
 Stage < 413 (48)7 (26)7 (26)27 (38)
 Stage 420 (45)18 (41)6 (14)44 (62)
Differentiation0.012
 Moderate or well29 (56)15 (29)8 (15)52 (74)
 Poor3 (17)8 (44)7 (39)18 (26)
Angiolymphatic invasion0.30
 No8 (47)6 (35)3 (18)17 (47)
 Yes7 (47)11 (58)1 (5)19 (53)
Perineural invasion0.57
 No7 (41)9 (53)1 (6)17 (50)
 Yes6 (35)8 (47)3 (18)17 (50)
ECS0.034
 No9 (64)2 (14)3 (21)14 (42)
 Yes5 (36)11 (58)3 (16)19 (58)
Locoregional recurrence0.88
 No22 (45)17 (35)10 (20)49 (62)
 Yes15 (50)10 (33)5 (17)30 (38)
Distant recurrence0.27
 No34 (50)21 (31)13 (19)68 (86)
 Yes3 (27)6 (55)2 (18)11 (14)
TP53 disruptive mutation0.90
 No27 (46)21 (36)11 (19)59 (75)
 Yes10 (50)6 (30)4 (20)20 (25)