Table 2.

NOTCH1 mutation compared with NICD1 IHC staining pattern

NICD1 IHC, pattern of staining
Positive, peripheralPositive, nonperipheralNegativeTotal
NOTCH1 mutationN (%)N (%)N (%)N (%)
 Wild-type34 (55)21 (34)7 (11)62 (78)
 Missense2 (25)4 (50)2 (25)8 (10)
 Truncating0 (0)1 (14)6 (86)7 (9)
 Missense and truncating1 (50)1 (50)0 (0)2 (3)
Total37 (47)27 (34)15 (19)79 (100)
P < 0.001
NICD1 IHC, positive vs. negative
PositiveNegativeTotal
NOTCH1 statusN (%)N (%)N (%)
 Wild-type55 (89)7 (11)62 (78)
 Mutated9 (53)8 (47)17 (22)
Total64 (81)15 (19)79 (100)
P = 0.002