Table 3.

Summary measures of the distribution of erlotinib concentration in plasma and normal mucosa at the follow-up visit by dosage level

Erlotinib dose
Characteristic25 mg50 mg100 mg
Plasma erlotinib concentration, ng/mL
N141413
 Median222.58480.951,118.34
 Mean (SD)232.29 (160.6)486.56 (211.8)1,280.84 (788.3)
Plasma OSI-420 concentration, ng/mL
N131413
 Median15.9236.9498.01
 Mean (SD)17.77 (12.3)33.87 (14.1)117.98 (84.5)
Normal mucosa erlotinib concentration, ng/mg
N121212
 Median0.321.101.68
 Mean (SD)0.36 (0.18)1.38 (1.23)3.25 (4.62)
Normal mucosa OSI-420 concentration, ng/mg
N41011
 Median0.040.140.23
 Mean (SD)0.04 (0.01)0.17 (0.15)0.29 (0.24)