Table 4.

Clinicopathologic characteristics associated with NOTCH1 mutation

NOTCH1 mutation status
Wild-typeMutatedTotal
Clinicopathologic characteristicsN (%)N (%)N (%)p-value
87 (83)18 (17)105 (100)
Age0.42
 ≤55 years38 (86)6 (14)44 (42)
 >55 years49 (80)12 (20)61 (58)
Sex0.061
 Male67 (87)10 (13)77 (73)
 Female20 (71)8 (29)28 (27)
Race0.91
 White73 (82)16 (18)89 (88)
 Other10 (83)2 (17)12 (12)
Tobacco0.83
 No27 (84)5 (16)32 (32)
 Yes57 (83)12 (17)69 (68)
Alcohol0.32
 No38 (86)6 (14)44 (52)
 Yes32 (78)9 (22)41 (48)
Site0.77
 Oropharynx26 (81)6 (19)32 (30)
 Other61 (84)12 (16)73 (70)
HPV status0.006
 Negative3 (43)4 (57)7 (24)
 Positive20 (91)2 (9)22 (76)
T Stage0.43
 T1-252 (85)9 (15)61 (65)
 T3-T426 (79)7 (21)33 (35)
N Stage0.18
 N028 (76)9 (24)37 (39)
 N1-N251 (86)8 (14)59 (61)
Overall stage0.33
 Stage<436 (88)5 (12)41 (42)
 Stage 445 (80)11 (20)56 (58)
Differentiation0.23
 Moderate or well53 (84)10 (16)63 (71)
 Poor19 (73)7 (27)26 (29)
Angiolymphatic invasion0.58
 No16 (80)4 (20)20 (48)
 Yes19 (86)3 (14)22 (52)
Perineural invasion0.52
 No20 (83)4 (17)24 (55)
 Yes18 (90)2 (10)20 (45)
ECS0.98
 No15 (88)2 (12)17 (40)
 Yes22 (88)3 (12)25 (60)
Locoregional recurrence0.86
 No55 (83)11 (17)66 (63)
 Yes32 (82)7 (18)39 (37)
Distant recurrence0.59
 No73 (82)16 (18)89 (85)
 Yes14 (88)2 (12)16 (15)
TP53 disruptive mutation0.66
 No67 (84)13 (16)80 (76)
 Yes20 (80)5 (20)25 (24)