Table 3.

Significant correlations between tissue omega-3 and omega-6 fatty acids and breast epithelial proliferation rate and cytomorphology

Lipid compartmentFatty acid or ratioSpearman ρP
Correlations with proliferation rate (% Ki-67)
 RBC PLEPA−0.260.033
 Breast PLLA0.320.038
AA0.340.025
 Breast TAGAA−0.330.038
Correlations with cytomorphology (Masood score)
 RBC PL20:2ω-60.270.023
22:2ω-6−0.280.024
DPAω-3−0.240.041
AA−0.280.017
 Plasma PLDPAω-3−0.250.034
EPA−0.240.042
 Plasma TAGEPA−0.240.045
 Breast TAGLA0.320.045
22:4ω-6−0.400.011
DPAω-3−0.490.0012
ω-3/ω-6−0.490.0013

NOTE: Significant correlations (P < 0.05 using Spearman rank correlation coefficient) of individual omega-3 and omega-6 fatty acids, and ratios, with proliferation (% Ki-67–positive nuclear staining) and cytomorphology (Masood score).