Table 1.

Data indicate median tumor number per mouse (including range from minimum to maximum) as a function of size (diameter in mm) and anatomical location (distal, middle, proximal) per experimental group

Nrf2+/+Nrf2−/−
GroupsAOM/DSSCA2 AOM/DSSCA11 AOM/DSSAOM/DSSCA2 AOM/DSSCA11 AOM/DSS
Distal
 <2 mm4.0 (2–7)3.0 (3–5)3.0 (1–9)5.0 (4–6)6.0 (5–8)5.5 (4–8)
 ≥2 mm3.0 (2–8)1.0 (1–3)a1.0 (1–2)a2.0 (2–3)2.0 (2–2)2.5 (0–4)
Middle
 <2 mm2.0 (0–5)3.0 (2–4)2.5 (0–5)3.5 (2–5)3.0 (2–4)3.0 (2–5)
 ≥2 mm2.0 (0–3)1.0 (0–2)a1.0 (0–2)a2.0 (1–3)2.0 (1–4)2.0 (0–3)
Proximal
 <2 mm3.0 (0–4)0.5 (0–3)0.0 (0–1)a1.5 (0–3)2.0 (0–2)2.0 (0–3)
 ≥2 mm1.0 (0–3)0.0 (0–0)a0.0 (0–0)a0.0 (0–2)0.0 (0–2)0.5 (0–2)
Total14.5 (12–20)10.0 (8–12)a9.0 (4–12)a14.5 (13–18)16.0 (12–20)15.0 (12–19)
  • aP < 0.05 compared with the “Nrf2+/+ AOM/DSS” group; Mann–Whitney test.