Table 1.

Relationship between TET1 methylation and clinicopathological features in our colorectal cancer cohort and TCGA database

Our cohortTCGA database
TotalTET1 methylatedTET1 unmethylatedTotalTET1 methylationTET1 unmethylated
Characteristicn = 168n = 25n = 143P-valuen = 593n = 79n = 514P-value
Age (years)
 ≧6593 (55)19 (20)74 (80)0.029356 (60)58 (16)298 (84)0.01
 <6575 (45)6 (8)69 (92)237 (40)21 (9)216 (91)
Gender
 Female81 (48)16 (20)65 (80)0.128274 (46)45 (16)229 (84)0.052
 Male87 (52)9 (10)78 (90)319 (54)34 (11)285 (89)
Locationa
 Proximal70 (42)20 (29)50 (71)<0.001254 (43)62 (24)192 (76)<0.001
 Distal98 (58)5 (5)93 (95)332 (57)16 (5)316 (95)
Histological
 Well/moderate126 (91)11 (9)115 (91)0.005516 (88)61 (12)455 (88)0.007
 Poor/mucinous12 (9)5 (42)7 (58)69 (12)17 (25)52 (75)
CIMP
 CIMP(+)55 (33)23 (42)32 (58)<0.001229 (39)75 (33)154 (67)<0.001
 CIMP(−)113 (67)2 (2)111 (98)364 (61)4 (1)360 (99)
  • Values in parentheses indicate percentages.

  • aProximal, cecum, ascending and transverse colon; Distal, descending and sigmoid colon and rectum.