Table 2.

Igf1r is among the top 20 persistently altered genes

HypermethylatedHypomethylated
GeneDiff MethFDRFeatureGeneDiff MethFDRFeature
Trp53bp237.903.86E−20IntronGprc5b−10.161.17E−04Intron
Nnat34.633.86E−20Ex/In/ShSim1−10.171.57E−07Ex/In
Frmd4a34.203.86E−20IntronDlg5−10.244.69E−03Intron
Clybl33.123.86E−20IntronNup88−10.433.86E−20In/Sh
Lhfpl232.663.86E−20IntronMtor−10.669.21E−04Intron
Rabep130.753.86E−20IntronEhhadh−10.703.86E−20Intron
Igf1r30.633.86E−20IntronPtgis−10.732.5E−02Intron
Fez129.993.86E−20IntronAsap3−10.795.86E−06Intron
Cdh429.973.86E−20IntronEif4e−10.912.37E−05Intron
Rbm2029.873.86E−20IntronSlc27a2−10.949.61E−04Intron
Cldn1429.843.86E−20IntronItga5−10.951.14E−05In/Sh
Unc5c29.431.57E−07IntronAsb2−10.951.26E−06Intron
Mapk428.811.57E−07IntronGm8066−11.000.000143Shore
Rap1gap28.063.86E−20Ex/InArhgap10−11.043.86E−20Intron
Vasp27.553.86E−20Ex/InUsp6nl−11.076.12E−07In/Sh
Myog27.103.86E−20ExonA930024E05Rik−11.132.96E−06In/Sh
Tspan727.033.86E−20IntronSlmo1−11.233.86E−20Intron
Zmym625.873.86E−20Prom/In/ShNcoa3−11.413.87E−07Intron
Gm961825.783.86E−20IntergenicAI662270−11.445.53E−04Prom/In
Nr2f225.643.86E−20In/ShMyom2−11.581.57E−07Intron

NOTE: Differentially methylated genes were identified by logistic regression and those that were altered early and remained altered later were considered persistently altered. A meta-analysis was used to compare the early and late time points to determine which changes we altered by parity and remained after 6.5 months. The differential methylation remaining at the late time point (Labeled “Trimmed_Means.2” in the Supplementary Data File) and FDR from the meta-analysis are listed as well as the genomic feature the differential methylation occurs exon (Ex), intron (In), CpGi shore (Sh), and promoter (Prom).