Table 4.

Significant (P < 0.05) changes in levels of 17 validated peptides and phosphopeptides in RPFNA specimens, assessed by RPPA

Number of paired specimens where values
Protein (see Supplementary Table for gene name)Antibody name and specific phosphorylation siteDecreaseIncreaseP (Wilcoxona 2-sided)
4E-BP14E-BP1_pS656150.010
AktAkt_pS4736150.050
BadBad_pS1128130.027
Metc-Met_pY1234_Y12351650.0064
Epidermal growth factor receptorEGFR4170.0087
Epidermal growth factor receptorEGFR_pY11731380.013
Her-2ErbB2/HER21740.0051
Lymphocyte-specific protein tyrosine kinaseLck1740.017
MEK1MEK11560.013
Myosin isoform IIaMyosin IIa_pS19431470.046
p27p27 KIP 1_pT1985160.0015
Rad50Rad503180.0078
Regulatory associated protein of mTORRaptor1740.0064
Anti-splicing factor-2SF2/ASF1560.013
Smad3Smad31470.025
TuberinTSC2 Tuberin_pT1462219<0.001
Y-box–binding protein 1YB-11740.0051
  • aP-values < 0.01 are indicated in bold.