Table 3.

Percentage of the surface area of the large airways with normal histology, atypia, LGD, and HGD after NTCU treatment

Treatment groupNNormalAtypiaLGDHGD
15 weeks of NTCU (15 μmol)
 S11100 ± 0
 SN1426 ± 17.963.5 ± 17.58.72 ± 9.5
 SN+C1438.5 ± 27.153.3 ± 23.36.6 ± 7.7
 D15100 ± 0
 DN103.8 ± 6.725.3 ± 10.548.3 ± 9.222.7 ± 8.8a,b
 DN+C120.8 ± 1.823.2 ± 21.363.1 ± 20.412.3 ± 13.9
25 weeks of NTCU (25 μmol)
 S1499.7 ± 1.10.3 ± 1.1
 SN134.9 ± 8.038.2 ± 16.248.5 ± 14.18.4 ± 7.7
 SN+C86.4 ± 1541.4 ± 28.740.4 ± 29.111.8 ± 15.6
 D1097.9 ± 5.32.1 ± 15.3
 DN73.5 ± 6.612.5 ± 35.648.5 ± 27.435.5 ± 21a,b
 DN+C105.42 ± 9.272.9 ± 14.921.3 ± 10.3

NOTE: Percentage of lesions is represented as the mean of total airways scored per group ± SEM; 3 sections (each ∼100 μm apart) were scored per mouse.

  • aSignificant P < 0.05 compared with S.

  • bSignificant P < 0.05 compared with SN.