Table 3.

IGF pathway members also display altered DNA methylation

EarlyLate
GeneTotal windowsSignificant windowsRatioHyperHypoTotal windowsSignificant windowsRatioHyperHypo
Irs13620.05560235190.5429190
Igf12630.11540325130.5200121
Igfbp42850.1786142090.450090
Stat5b8170.08643485360.42351818
Prlr2930.10340329120.4138120
Shc2110.0476012180.381080
Igfbp31100.000000830.375030
Igf2r3240.12501328100.357173
Igfbp6300.000000310.333310
Ghr4550.11110545140.3111131
Akt12200.0000002060.300060
Akt22920.0690022980.275980
Irs246100.217401045120.2667120
Sos2710.0370103490.264736
Stat5a1600.0000002360.260942
Src5010.02001048100.2083100
Stat35160.11763354100.185255
Erk1200.0000001320.153820
Igfbp21400.0000001210.083301
Irs41900.0000002010.050010
Igfbp5300.000000300.000000
PI3K200.000000200.000000
Igfbp1200.000000200.000000

NOTE: The total number of 120-bp windows available for each gene was compared with the number of windows that were significantly differentially methylated with parity to obtain the ratio.