Table 3.

Change in risk and response biomarkers for 34 subjects who completed the trial

BiomarkerMedian prestudyMedian poststudyMedian absolute changeMedian relative changeP Wilcoxon (McNemar)
RPFNA specimens
Masood score1514−1−7%<0.001
Frequency of atypia, percent77382 “gain” atypia0.0024
15 “lose” atypia
Estimated epithelial cell number per slide1–5 × 1031–5 × 10316 decrease0.0015
3 increase
Ki-67, percent2.11.0−1.5−62%0.021a
Mammographic breast density
Percent area of increased density (average of two readers)16.815.8−1.9−17%0.0036
  • aIf omit one baseline specimen exhibiting 0% (not possible to decrease), then P = 0.0091. P-values < 0.05 are indicated in bold.