Table 2.

Changes in (a) cytomorphology and Ki-67 in RPFNA specimens and (b) mammographic breast density over the course of the study

BiomarkerBaselinePostinterventionAbsolute changeRelative changeP
Masood Score1514−1−7%0.10
14–179–17−5–2−36%–14%
[14–15][13–16][−2–1][−14%–7%]
14.8 ± 1.014.0 ± 2.2−0.8 ± 2.0−5% ± 14%
14 decrease
9 increase
Atypia13 (52%)12 (48%)4 “gain” atypia1.00
5 “lose” atypia
Estimated epithelial cell number per slide
 1 × 102 to 5 × 1020 (0%)4 (16%)10 decrease0.012
 5 × 102 to 1 × 1032 (8%)5 (20%)2 increase
 1 × 103 to 5 × 10318 (72%)12 (48%)
 >5 × 1035 (20%)4 (16%)
Ki-67, %4.61.4−3.0−77%<0.001
2.4–21.80.0–6.6−20.2–2.8−100%–117%
[3.1–8.5][0.6–3.5][−7.1–−2.0][−88%–−52%]
6.6 ± 4.82.1 ± 1.9−4.5 ± 4.7−57 ± 52%
23 decrease
2 increase
Mammographic breast density (percentage of area at increased density)35.835.0−3.9−11%0.067
2.9–76.33.6–70.8−31.4–16.2−49%–71%
[21.1–60.8][18.5–48.8][−10.0–0.9][−23%–4%]
40.5 ± 22.536.3 ± 20.2−4.2 ± 10.3−5 ± 30%
16 decrease
8 increase

NOTE: Median, range [IQR], and mean, ± SD are shown for the 25 subjects, except mammographic density where only 24 comparisons were available.