Table 4.

Median (inter-quartile range) levels of plasma inflammatory markers according to characteristics of colorectal adenoma among case participants in the Nurses' Health Study (1990)a

CharacteristicMIC-1, ng/LCRP, mg/LIL6, ng/LsTNFR-2, μg/L
Number of adenoma
 Single (n = 482)580 (485–742)1.94 (0.92–3.86)0.93 (0.62–1.62)2.69 (2.32–3.13)
 Multiple (n = 252)659 (517–856)1.88 (0.78–4.45)1.02 (0.62–1.58)2.67 (2.26–3.22)
P<0.0010.890.610.91
Size of adenoma
 <1 cm (n = 114)587 (474–772)1.73 (0.84–3.60)0.96 (0.65–1.50)2.63 (2.37–3.03)
 ≥1 cm (n = 613)614 (497–783)1.94 (0.90–4.07)0.97 (0.62–1.59)2.70 (2.29–3.18)
P0.130.470.840.58
Location
 Proximal colon (n = 206)616 (513–788)2.08 (0.88–3.85)0.91 (0.61–1.50)2.71 (2.27–3.20)
 Distal colon (n = 298)592 (480–753)1.81 (0.88–4.04)0.93 (0.60–1.50)2.66 (2.33–3.09)
 Rectum (n = 98)568 (487–759)2.00 (1.21–3.71)1.10 (0.67–1.93)2.65 (2.26–3.10)
 Multiple adenomas in ≥2 locations (n = 131)638 (508–823)1.81 (0.75–4.46)1.06 (0.62–1.57)2.83 (2.32–3.33)
P0.120.790.160.30
Histologic type
 Tubular adenoma (n = 247)612 (494–778)2.00 (0.84–4.06)0.93 (0.60–1.59)2.72 (2.33–3.20)
 Tubulovillous, villous adenoma or high-grade dysplasia (n = 400)607 (489–786)1.88 (0.91–4.15)0.99 (0.62–1.68)2.67 (2.32–3.13)
P0.910.360.350.63

Abbreviations: CRP, C-reactive protein; MIC-1, macrophage inhibitory cytokine-1; sTNFR-2, soluble tumor necrosis factor receptor 2.

  • aAdenoma characteristics were missing for some cases and thus the total number of cases may not add up to 757.