Table 1.

Rexinoids prevent lung cancer in A/J mice challenged with vinyl carbamate

LG100268LG101506
Control40 mg/kg diet40 mg/kg diet
Tumor number, size, and burden
 Number of slides1124848
 Average number of tumors (% control)3.55 ± 0.17 (100%)2.33 ± 0.25a,b (66%)3.04 ± 0.27b,c (86%)
 Average tumor size, mm3 (% control)0.36 ± 0.02 (100%)0.20 ± 0.04a (54%)0.21 ± 0.02a (59%)
 Average tumor burden, mm3 (% control)1.29 ± 0.12 (100%)0.46 ± 0.12a,b (36%)0.65 ± 0.07a,b (50%)
Tumor histopathology
 Number of tumors398112146
 Total number of low-grade tumors (% total)24 (6%)17a (15%)20a (14%)
 Total number of medium-grade tumors (% total)172 (43%)55 (49%)74 (51%)
 Total number of high-grade tumors (% total)202 (51%)40a (36%)52a (35%)

NOTE: Female A/J mice were injected i.p. with two doses of vinyl carbamate (0.32 mg/mouse) 1 week apart. One week after the last treatment of carcinogen, mice were fed for 16 weeks with either control diet or rexinoids at a dose of 40 mg/kg diet. Values represent mean ± SEM of two independent pooled studies.

  • aP < 0.05 for all compounds vs. control.

  • bP < 0.05 for LG268 40 vs. LG1506 40 mg/kg diet.

  • cP = 0.062 for LG1506 40 vs. control.