Table 2.

Glycan features from the discovery sample set meeting performance criteriaa for test set evaluation, together with their putative structure, and median, AUC, and P values in both the discovery and test sample sets

DiscoveryTest
GlycanGlycan FeatureGlycan variableaNSCLC (median, N = 98)Control (median, N = 194)AUCPbFDRpAUC (0.10)cNSCLC (median, N = 108)Control (median, N = 216)AUCPbFDR
XGal_1−6.34E−022.46E−020.66>0.0010.0176.43E−06−7.06E−029.24E−030.611.06E−030.007
XGal_3−3.42E−021.89E−020.660.0010.0141.35E−05−6.18E−021.57E−020.611.65E−030.007
XGal_4−7.05E−021.50E−020.650.0010.0151.97E−05−7.42E−023.78E−020.581.56E−020.040
XGal_5−7.64E−021.59E−020.650.0010.0112.37E−05−1.21E−013.67E−020.541.94E−010.195
XSia_22.85E+00−9.04E−010.650.0010.0092.59E−051.51E+00−2.77E−010.574.34E−020.056
XH6N5F1−4.40E−052.20E−050.640.0010.0076.71E−05−1.30E−051.60E−070.573.17E−020.056
XSia_15.05E+01−1.02E+010.640.0020.0061.54E−042.10E+01−4.51E+000.581.85E−020.040
XTr5.80E−03−2.23E−030.630.0040.0132.73E−046.27E−03−1.18E−050.574.21E−020.056
XGal_2−1.56E−015.63E−020.630.0050.0123.84E−04−1.17E−012.15E−020.602.45E−030.008
XH5N4F1−1.30E−034.90E−040.620.0050.0065.40E−04−2.00E−031.20E−030.643.61E−05>0.001
XH3N4F13.20E−03−1.50E−030.610.0100.0141.38E−033.10E−03−8.70E−040.566.86E−020.081
XH3N46.70E−04−1.40E−040.600.0250.0093.82E−035.90E−04−2.00E−030.541.95E−010.195
  • aGlycan variables identified for testing were those with AUC > 0.60 and an FDR < 0.05.

  • bP values calculated using the Wilcoxon test.

  • cpAUC associated with a false positive rate (FPR) upper bound of 0.10 (i.e., AUC for the FPR range of 0–0.10).