Table 5.

Association between TDLU and nondense area/volume MD measures among premenopasual women with benign breast disease, The BREAST Stamp Project

Nondense area/volume measures
Nondense area (cm2)Nondense volume (cm3)Nondense perilesional volume (cm3)
UnadjustedAdjustedaUnadjustedAdjustedaUnadjustedAdjusteda
TDLU measureNbMean95% CIMean95% CIMean95% CIMean95% CIMean95% CIMean95% CI
TDLU count/100 mm2
 061122.3107.0–137.6110.5100.7–120.4477.6407.4–547.7400.7350.5–451.013.810.4–17.310.77.6–13.7
 1.0–<11.348108.093.8–122.3110.599.6–121.4380.9309.0–452.8389.1334.6–443.59.67.0–12.211.38.5–14.1
 11.3–<22.74975.865.1–86.490.681.1–100.1274.4217.4–331.5341.0296.1–385.910.77.4–13.912.49.2–15.6
 22.7–<48.34979.668.5–90.895.785.1–106.2280.7222.7–338.6352.6300.5–404.86.74.6–8.89.36.9–11.8
 48.3–199.24860.252.3–68.184.575.0–93.9168.2134.0–202.4286.0242.1–329.97.75.0–10.511.17.7–14.4
P value for trend<0.00010.004<0.00010.020.030.85
Median TDLU span, μ
 78–<2113898.283.7–112.7112.8101.3–124.2355.9283.2–428.5421.7368.3–475.17.85.2–10.49.87.0–12.5
 211–<2603979.766.8–92.792.179.2–104.9275.3210.3–340.4325.6268.9–382.47.75.5–9.98.86.2–11.4
 260–<3023980.566.9–94.199.787.6–111.8267.8199.6–336.1350.2286.8–413.78.75.8–11.510.67.1–14.0
 302–<3853971.560.0–82.985.674.9–96.4226.1170.9–281.3294.1243.9–344.38.35.1–11.49.46.4–12.5
 385–8093972.361.3–83.386.276.8–95.7241.6186.7–296.5292.2246.3–338.111.07.1–14.812.28.4–16.1
P value for trend0.040.010.060.0090.340.40
Median acini count per TDLU
 1–106287.776.0–99.3105.795.9–115.6295.7238.7–352.8377.6330.3–425.05.64.1–7.17.55.8–9.1
 10.5–16.56284.275.4–93.092.383.6–101.1296.9250.6–343.2329.6288.8–370.311.38.7–13.912.29.2–15.3
 17–686767.558.3–76.781.873.2–90.5216.9172.8–261.0279.9238.4–321.39.16.4–11.810.87.6–14.0
P value for trend0.050.020.120.040.120.12

NOTE: P values <0.05 are presented in bold font.

Abbreviations: CI, confidence interval; TDLU, terminal duct lobular unit.

  • aModels were adjusted for age, BMI, history of breast biopsy, and pathologic diagnosis. TDLU counts were additionally adjusted for smoking status and biopsy type.

  • bN represents the number of biopsy targets.