Table 3.

Association between TDLU and percent dense area/volume MD measures among premenopausal women with benign breast disease, The BREAST Stamp Project

Percent dense area/volume measures
Percent dense area (%)Percent fibroglandular volume (%)Percent perilesional fibroglandular volume (%)
UnadjustedAdjustedaUnadjustedAdjustedaUnadjustedAdjusteda
TDLU measureNbMean95% CIMean95% CIMean95% CIMean95% CIMean95% CIMean95% CI
TDLU count/100 mm2
 06121.317.6–25.024.621.4–27.733.129.8–36.438.335.1–41.536.832.7–40.941.036.3–45.7
 1.0–<11.34826.922.6–31.127.523.0–32.038.733.9–43.440.135.9–44.441.236.0–46.542.036.8–47.2
 11.3–<22.74936.832.7–40.934.329.7–38.945.941.3–50.643.739.6–47.951.546.3–56.747.542.2–52.8
 22.7–<48.34929.325.5–33.027.023.4–30.643.138.5–47.740.836.9–44.752.046.5–57.547.642.6–52.6
 48.3–199.24836.732.9–40.631.927.2–36.552.048.1–55.944.840.7–49.059.554.9–64.149.944.8–55.0
P value for trend0.00030.07<0.00010.11<0.00010.03
Median TDLU span, μ
 78–<2113827.724.1–31.325.021.7–28.437.933.3–42.435.832.1–39.542.737.0–48.340.635.4–45.8
 211–<2603930.825.5–36.229.223.5–35.043.438.1–48.741.937.0–46.850.844.9–56.748.743.0–54.4
 260–<3023929.525.3–33.726.322.3–30.243.638.4–48.840.536.0–45.150.044.0–56.045.740.4–51.1
 302–<3853939.334.7–43.937.032.0–41.950.945.8–55.947.543.0–52.159.052.7–65.254.448.7–60.1
 385–8093934.930.3–39.532.727.7–37.748.643.4–53.747.142.3–51.952.446.6–58.350.044.2–55.8
P value for trend0.020.010.020.0030.040.04
Median acini count per TDLU
 1–106230.827.0–34.727.924.2–31.542.938.6–47.339.736.0–43.450.945.9–55.947.242.5–51.9
 10.5–16.56230.327.1–33.630.025.6–34.442.339.0–45.642.238.7–45.748.144.4–51.947.342.9–51.6
 17–686736.032.2–39.833.829.1–38.549.545.1–53.847.042.6–51.554.249.0–59.450.645.3–55.9
P value for trend0.180.140.140.060.500.57

NOTE: P values <0.05 are presented in bold font.

Abbreviations: CI, confidence interval; MD, mammographic density; TDLU, terminal duct lobular unit.

  • aModels were adjusted for age, BMI, history of breast biopsy, and pathologic diagnosis. TDLU counts were additionally adjusted for smoking status.

  • bN represents the number of biopsy targets.