Table 1.

Participant characteristics of CARET NSCLC cases and controls

Discovery setTest set
CasesControlsCasesControls
(N = 100)(N = 199)(N = 108)(N = 216)
Agea, mean (SD)61.1 (5.8)60.9 (5.9)61.9 (5.7)61.9 (5.9)
Pack-years, mean (SD)b57 (23)47 (22)54 (23)49 (20)
Age at diagnosis, mean (SD)66.2 (6.2)65.1 (6.3)
Sexa
 Male7514975150
 Female25503366
Race
 White9418599200
 Black3568
 Other3938
Exposure population
 Asbestos-exposed worker31563553
 Heavy Smoker6914373163
Smoking status at baselinea
 Current6112172144
 Former39783672
Histology
 Adenocarcinoma4040
 Squamous cell3038
 Other/unspecified NSCLC3030
Stage
 I–II1426
 III–IV6964
 Unknown1718
Months from blood collection to diagnosis
 <6 months4840
 6–12 months5268
  • aMatching variables.

  • bCase versus control difference for pack-years is statistically significant among the discovery and validation sets, Wilcoxon test P = 0.0005 and P = 0.009, respectively.