Table 4.

Association between TDLU and absolute dense area/volume MD measures among premenopasual women with benign breast disease, The BREAST Stamp Project

Absolute dense area/volume measures
Absolute dense area (cm2)Absolute fibroglandular volume (cm3)Absolute perilesional fibroglandular volume (cm3)
UnadjustedAdjustedaUnadjustedAdjustedaUnadjustedAdjusteda
TDLU measureNbMean95% CIMean95% CIMean95% CIMean95% CIMean95% CIMean95% CI
TDLU count/100 mm2
 06129.825.2–34.432.927.8–38.1213.0194.6–231.4219.4198.9–239.97.76.4–9.07.56.0–9.0
 1.0–<11.34838.832.3–45.441.233.1–49.2219.1190.4–247.8233.5202.6–264.47.65.6–9.78.26.0–10.5
 11.3–<22.74944.138.8–49.446.939.8–53.9209.8190.9–228.6233.0210.3–255.811.59.0–14.010.98.4–13.4
 22.7–<48.34932.027.5–36.434.628.8–40.4180.2162.7–197.7203.3180.2–226.47.05.6–8.57.35.6–9.0
 48.3–199.24834.330.0–38.536.930.1–43.7170.4151.3–189.5199.3174.4–224.310.27.8–12.69.67.1–12.1
P value for trend0.670.750.0090.170.320.50
Median TDLU span, μ
 78–<2113835.030.8–39.134.829.5–40.2184.7163.0–206.5200.2174.6–225.85.84.3–7.36.75.0–8.4
 211–<2603936.729.2–44.338.930.0–47.9192.5167.8–217.1210.5185.8–235.38.26.5–9.98.56.3–10.8
 260–<3023931.427.3–35.633.127.3–39.0176.3156.9–195.7200.2173.3–227.08.76.0–11.39.05.7–12.3
 302–<3853946.540.4–52.749.541.0–57.9219.3195.3–243.3242.4212.1–272.811.38.9–13.811.18.7–13.5
 385–8093937.432.2–42.739.531.9–47.2200.2178.3–222.2221.5192.0–251.011.78.8–14.512.29.4–15.0
P value for trend0.250.140.270.170.0030.003
Median acini count per TDLU
 1–106237.833.1–42.639.633.4–45.8194.7176.3–213.1216.9193.2–240.76.35.1–7.46.85.3–8.3
 10.5–16.56237.032.3–41.739.932.5–47.2200.0181.6–218.4220.6197.4–243.910.68.5–12.711.18.6–13.6
 17–686737.233.1–41.240.032.7–47.2191.3174.5–208.0216.5189.6–243.410.48.3–12.410.98.5–13.2
P value for trend0.890.980.840.940.010.02

NOTE: P values <0.05 are presented in bold font.

Abbreviations: CI, confidence interval; MD, mammographic density; TDLU, terminal duct lobular unit.

  • aModels were adjusted for age, BMI, history of breast biopsy, and pathologic diagnosis.

  • bN represents the number of biopsy targets.