Table 3.

Urinary levels of [pyridine-D4]NNK metabolites by PEITC treatment, The PEITC Intervention Study 2008–2013

Geometric mean (pmol/mg creatinine)
Urinary metabolites of [pyridine-D4]NNKPlacebo (n = 82)PEITC (n = 82)% difference (95% CI)P for differencea
Total [pyridine-D4]NNAL (pmol/mg creatinine)0.3360.336−0.1 (−8.5–9.1)0.980
[pyridine-D4]Hydroxy acid (pmol/mg creatinine)0.1500.140−6.7 (−13.8–1.0)0.092
[pyridine-D4]Hydroxy acid: total [pyridine-D4]NNAL ratio0.4550.420−7.7 (−13.8–−1.2)0.023
  • aTwo-sided P values were for PEITC treatment effect and derived from the mixed model.