Table 1.

VEGF levels at baseline and after 12 months by the treatment arm (n = 62)

Control (n = 33)Fenretinide (n = 29)Pa
Baseline, pg/mL
Mean ± SD233.3 ± 133.4263.1 ± 162.10.4
Median (IQR)201.3 (132.8–277.3)245.8 (135.2–313.3)
Bottom quintile72.2–123.188.2–124.6
2nd quintile127.0–187.5129.6–176.9
3rd quintile189.3–229.3217.4–254.4
4th quintile230.3–351.8278.2–347.6
Top quintile371.6–608.0423.2–741.7
After 1 year, pg/mL
Mean ± SD219.2 ± 132.0224.0 ± 133.40.7
Median (IQR)166.8 (136.1–268.5)201.5 (137.5–275.3)
Bottom quintile57.1–124.552.5–119.5
2nd quintile125.0–157.6131.8–178.6
3rd quintile161.5–191.3183.2–211.3
4th quintile206.6–310.0212.3–302.2
Top quintile370.8–641.1323.3–605.7
  • aMann–Whitney test. Difference in VEGF levels (independently from treatment arm) between baseline and 24 months: Wilcoxon signed-rank test P = 0.007.