Table 2.

log2solCD44, and protein levels in oral rinses of R01 HNSCC study by patient group and key variables

log2 [solCD44 (ng/mL)]Protein (mg/mL)
CasesControlsCasesControlsCasesControls
NNMeanSEMeanSEPMeanSEMeanSEP
All1501501.94a0.091.28a0.07<0.00010.94a0.050.76a0.030.003
Site of enrollment
 JMH80711.96a0.141.32a0.11<0.00010.95w0.070.81w0.050.017
 UM70791.92b0.111.26b0.090.93a0.060.73a0.04
Age
 <6084851.71a,c0.121.16a,w0.08<0.00010.88w0.060.75w0.040.010
 60 or more66652.24b,c0.141.45b,w0.121.00a0.070.78a0.05
Gender
 Male1211182.01a0.101.29a0.08<0.00010.96a0.050.80a0.040.006
 Female29321.680.211.280.160.86w0.100.64w0.07
Race/Ethnicity (n)(149)(148)
 White Non-Hispanic53291.93a0.151.31a0.14<0.0010.91a0.080.68a0.070.017
 White Hispanic70891.91b0.131.32b0.080.910.070.810.04
 Black26302.06c0.261.14c0.191.08b0.120.71b0.07
SES
 Low100901.92a0.121.36a0.09<0.00010.95w0.060.81w0.040.009
 High50601.98b0.141.17b0.100.91a0.070.69a0.04
Smoking status
 Never33321.72a0.201.23a0.13<0.00010.960.140.760.060.027
 Ever1171182.01b0.101.30b0.080.93a0.050.76a0.04
 Never33321.72a0.201.23a0.13<0.00010.940.140.760.060.080
 Former37592.13b0.181.31b0.100.98a0.090.78a0.06
 Current80591.95c0.131.29c0.120.91w0.050.75w0.05
In current smokers (n)(75)(52)
<20 pack-years33291.86a0.181.07a0.200.0030.960.080.710.070.203
≥20 pack-years42231.99w0.191.51w0.140.840.080.810.09
Alcohol past
 Non-drinker35402.08a0.191.38a0.13<0.00011.00a0.090.73a0.050.018
 Drinker (Mild/Mod/Heavy)1151101.90b0.111.25b0.080.92b0.050.78b0.04
Alcohol current (n)(148)(148)
 Non-drinker84721.87a0.121.40a0.10<0.00010.97w0.070.82w0.050.010
 Drinker (Mild/Mod/Heavy)64762.04b0.151.17b0.100.91a0.060.72a0.04
Alcohol status
 Never33302.08a0.201.39a0.16<0.00011.01a0.100.75a0.070.019
 Ever1171201.90b0.101.26b0.080.92b0.050.77b0.04
Teeth removed
 None/1 to 586921.82a,d0.111.26a0.08<0.00010.90a0.050.74a0.040.020
 ≥6, but not all36391.79b0.151.25b0.140.81b0.060.760.07
 All24152.33c.d0.261.43c0.201.05b0.130.840.10
Gargle (n)(138)(143)
Poor/Fair38122.23a.c0.220.88a0.36<0.00011.13a,b0.110.66a0.13<0.001
Good1001311.82b,c0.101.29b0.070.85b0.050.770.03
Cancer site
 Lip/OC592.120.150.1320.980.090.490
 Oropharyngeal911.830.110.910.05
Stage
 Stage I/II261.780.170.4250.900.090.719
 Stage III/IV1241.980.110.940.05
T-stage
 T1-T2631.76w0.120.0880.890.050.431
 T3-T4872.07w0.130.970.07
N-stage
 N0, Nx511.970.140.8480.950.080.850
 N1-N3991.930.120.930.06
HPV (n)(79)
HPV+311.900.230.7600.880.090.997
HPV-481.990.160.880.08
  • NOTE: Same letters identify pairwise mean comparison within group or within a category of a key variable that was significant at the 5% level (letters a, b, c) or at the 10% level (letters w, y) by Fisher least significant difference test.

  • Abbreviations: (n), total cases or total controls excluding missing data; OC, oral cavity; OP, oropharynx; P: P value from ANOVA global test of equality of all means.