Table 4.

Unadjusted and adjusted linear regression models for 25(OH)D, 1,25 (OH)2D, and baseline fecal bile acid concentrations

25(OH)D (ng/mL)1,25(OH)sD (pg/mL)
Baseline bile acidβ-coefficient (SE)β-coefficient (SE)
concentrations (μg/mL)UnadjustedPaAdjustedbPaUnadjustedPaAdjustedbPa
Total bile acids−4.49 (1.40)<0.001−2.56 (1.50)0.09−1.45 (0.25)0.25−0.80 (1.28)0.54
Primary−1.64 (0.62)<0.01−1.21 (0.67)0.07−0.64 (0.56)0.26−0.41 (0.57)0.48
Secondary−2.86 (1.00)<0.01−1.25 (1.07)0.21−0.81 (0.90)0.37−0.39 (0.91)0.67
Chenodeoxycholic−0.28 (0.11)<0.01−0.32 (0.12)<0.01−0.01 (0.02)0.55−0.08 (0.10)0.46
Cholic−1.36 (0.56)<0.05−0.88 (0.60)0.14−0.003 (0.003)0.26−0.33 (0.52)0.52
Lithocholic−0.26 (0.09)<0.01−0.20 (0.09)<0.050.02 (0.02)0.360.10 (0.08)0.21
Deoxycholic−1.74 (0.49)<0.001−0.61 (0.43)0.160.002 (0.004)0.720.35 (0.37)0.35
Ursodeoxycholic−0.16 (0.27)0.55−0.16 (0.27)0.55−0.01 (0.006)0.08−0.46 (0.25)0.06
Ursocholic−0.28 (0.62)0.66−0.28 (0.62)0.66−0.001 (0.003)0.840.07 (0.58)0.90
Otherc−0.77 (0.20)<0.001−0.61 (0.22)<0.01−0.02 (0.008)<0.01−0.45 (0.19)<0.05
  • aP value calculated using linear regression modeling.

  • bModels adjusted for age, sex, and BMI.

  • cOther includes isodeoxycholic, isoursodeoxycholic, 7-ketolithocholic, and 12-ketolithocholic acids.