Table 3.

Correlation between Cumulative Methylation and clinical risk factors, and between age or Masood cytology score and individual gene methylation

NSpearman r (95% CI)P-value
Correlation between Cumulative Methylation and Clinical Risk Factors
Age357−0.048 (−0.154 to 0.059)0.367
Lifetime Gail Assessment3560.005 (−0.103 to 0.111)0.933
Percent Density3560.0966 (−0.011 to 0.2020.069
Masood Score3320.385 (0.287 to 0.476)< 0.0001
Correlation between Age and Individual Gene Methylation
RASSF1357−0.085 (−0.190 to 0.022)0.1102
TWIST1357−0.041 (−0.148 to 0.066)0.436
CCND2355−0.040 (−0.015 to 0.068)0.455
HIN1357−0.036 (−0.142 to 0.071)0.496
RARB3570.172 (0.067 to 0.274)0.001
AKR1B1357−0.119 (−0.223 to 0.012)0.024
TM6SF13570.024 (−0.083 to 0.1300.656
TMEFF2357−0.003 (−0.110 to 0.104)0.953
Correlation between Masood Cytology and Individual Gene Methylation
RASSF13320.413 (0.316 to 0.501)< 0.0001
TWIST13320.301 (0.195 to 0.397)< 0.0001
CCND23310.464 (0.372 to 0.547)< 0.0001
HIN13320.312 (0.208 to 0.408)< 0.0001
RARB332−0.0927 (−0.201 to 0.083)0.092
AKR1B13320.253 (0.146 to 0.354)< 0.0001
TM6SF13320.228 (0.121 to 0.331)< 0.0001
TMEFF23320.025 (−0.086 to 0.135)0.652