Table 3.

Unanswered questions and future research

Epidemiology and Risk Factors
  • Population level incidence, prevalence, and trends using accurate classification and selection

  • Incidence and risk for dysplasia and colitis-associated CRC with strictures and identifying strictures associated with an increased risk for harboring dysplasia or colitis-associated CRC

  • Incremental impact of having multiple risk factors present at baseline or over time

Molecular Basis and Targets of Carcinogenesis
  • Whole-exome sequencing of early dysplasia to understand sequence of genetic alterations

  • Predictive and prognostic importance of genetic alterations for progression to CRC

  • Targeted chemoprevention and personalized treatment of early dysplastic lesions with a particular emphasis on NF-κB inhibition, anti-interleukin, and anti-cytokine biologics

Surveillance and Endoscopic Management
  • Risk-stratified surveillance techniques and impact on disease outcomes

  • Noninvasive surveillance techniques (stool- or blood-based DNA testing)

  • Comparative effectiveness of enhanced visualization techniques