| Epidemiology and Risk Factors |
Population level incidence, prevalence, and trends using accurate classification and selection Incidence and risk for dysplasia and colitis-associated CRC with strictures and identifying strictures associated with an increased risk for harboring dysplasia or colitis-associated CRC Incremental impact of having multiple risk factors present at baseline or over time
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| Molecular Basis and Targets of Carcinogenesis |
Whole-exome sequencing of early dysplasia to understand sequence of genetic alterations Predictive and prognostic importance of genetic alterations for progression to CRC Targeted chemoprevention and personalized treatment of early dysplastic lesions with a particular emphasis on NF-κB inhibition, anti-interleukin, and anti-cytokine biologics
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| Surveillance and Endoscopic Management |
Risk-stratified surveillance techniques and impact on disease outcomes Noninvasive surveillance techniques (stool- or blood-based DNA testing) Comparative effectiveness of enhanced visualization techniques
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