Table 1.

Chemoprevention for serrated polyps

Chemopreventive strategyPreventive effectFollow-up durationProposed mechanismSite of actionMagnitudeReference
Aspirin 81 mg/dYes3 yInhibition of prostaglandins/eicosanoidsProximal serrated polypsRR, 0.56 (0.34–0.91)(54)
Aspirin 325 mg/dYes3 yInhibition of prostaglandins/eicosanoidsProximal serrated polypsRR, 0.58 (0.36–0.95)
Aspirin (> 4 times/mo)Yes1 yInhibition of prostaglandins/eicosanoidsHyperplastic polypsOR, 0.8 (0.7–0.9)(83)
Aspirin + ibuprofenYes1 yInhibition of prostaglandins/eicosanoidsHyperplastic polypsOR, 0.7 (0.6–0.9)
Folic acid, 1 mg/dNo3 yInvolved in DNA synthesisProximal advanceda serrated polypsRR, 2.07 (1.14–3.77)(54, 90)
Distal advanceda serrated polypRR, 0.98 (0.61–1.57)
Calcium 1,200 mg/dNo4 yInhibition of colonic epithelial proliferationSerrated polyps(54, 95, 96)
β-CaroteneNo4 yPresumed antioxidant effect(54, 92)
Vitamin CNo
Vitamin ENo
Hormone replacement therapyNo1–9 yearsUnknownSerrated polyps1.09 (0.76, 1.57)(49)
  • aAny serrated lesion >1 cm, SSA/P or TSA, or mixed polyps.