Table 1.

Baseline characteristics of current users of metformin or other NIADs

Current metformin usersCurrent other NIADs users
Characteristicn = 37,215n = 19,899P valuea
 Age (mean, SD)63.512.767.012.9<0.01
 Sex (n, % male)18,15148.89,35347.0<0.01
 Year of index date (mean, SD)20063.420023.4<0.01
ADD use (n, %)b
 Metformin37,215100.000.0<0.01
 SU4,62112.419,16696.3<0.01
 Thiazolidinediones3571.06323.2<0.01
 Meglitinides90.0540.3<0.01
 Incretins710.2530.30.06
Use of other drugs (n, %)c
 Antihypertensives21,65358.210,24651.5<0.01
 Aspirin6,32617.03,10215.6<0.01
 Bisphosphonates9222.55492.80.04
 H. pylori eradication therapy410.190.10.01
 Non-aspirin NSAIDs4,83213.02,63013.20.43
 Proton pump inhibitors6,47817.42,70213.6<0.01
 Statins14,89840.04,40822.2<0.01
History of hospitalization (n, %)
 0 hospitalizations22,62160.814,31071.9
 ≥1 hospitalizations14,59439.25,58928.1<0.01
  • aP value based on Mann–Whitney U test for continuous variables and χ2 test for categorical variables.

  • bAt the start of follow-up (t0),

  • cDuring 90 days before the index date.