Table 2.

Total and free EGCG levels in plasma, urine, breast cancer, and adjacent unaffected breast tissue in patients who received Greenselect Phytosome for 28 days

TimeMedianQ1Q3MinMaxP
Total EGCG (plasma) ng/mLBaseline00000
Before last administration20.314.730.71.3241.43
2 hours after last administration8950.9111.417.4121.2<0.008a
Free EGCG (plasma) ng/mLBaseline00000
Before last administration00000
2 hours after last administration30.916.638.6065.8<0.001a
Total EGCG (urine) ng/mLbBaseline00000
Surgery4.573.325.382.056.380.002
Free EGCG (urine) ng/mLbBaseline00000
Surgery000001.0
Total EGCG (tissue) ng/gTumor3.182.764.581.188.560.02
Normal breast tissue002.3402.85
Free EGCG (tissue) ng/gTumor000000.004
Normal breast tissue1.0701.2501.46
  • aP for the difference between before last administration and 2 hours after last administration.

  • bCreatinine normalization; end: before the last administration; end-2h: 2 hours after the last administration.