Table 1.

Th17 cytokine concentrations in colorectal tissue protein extracts

Exploratory set (16 pairs)Confirmatory set (12 pairs)
CytokineaNormalTumorP valueNormalTumorP value
IL17F122.26 ± 3.94163.9 ± 17.560.04260156.2 ± 4.54167.9 ± 7.690.05858
CSF226.76 ± 6.05211.0 ± 79.740.0394445.6 ± 11.58137.9 ± 38.700.05431
IFNG10.18 ± 0.5112.2 ± 0.940.0853830.7 ± 12.94100.2 ± 27.020.04850
IL1023.28 ± 11.4131.0 ± 10.780.6470697.1 ± 43.2848.4 ± 12.020.23779
CCL201589.38 ± 296.388025.6 ± 1091.380.000051063.7 ± 280.376222.8 ± 989.850.00013
IL12B35.03 ± 3.6037.2 ± 2.310.6348462.3 ± 5.4262.8 ± 4.010.87171
IL1384.54 ± 5.6482.8 ± 6.730.8411484.9 ± 15.8049.9 ± 8.300.08219
IL15112.43 ± 13.32147.6 ± 15.650.17259154.6 ± 33.06202.2 ± 19.920.26086
IL17A86.80 ± 2.50153.5 ± 20.860.0074432.6 ± 10.93113.2 ± 33.870.01359
IL22107.40 ± 7.41126.7 ± 9.070.10175140.3 ± 11.91147.8 ± 5.540.47986
IL959.10 ± 2.5154.7 ± 3.390.2766038.7 ± 7.0647.7 ± 9.700.47586
IL1B45.98 ± 6.821993.8 ± 1103.840.0973728.9 ± 5.201618.5 ± 1100.050.17671
IL332377.08 ± 369.512992.5 ± 683.670.382701500.9 ± 202.022365.1 ± 602.960.13696
IL287.01 ± 2.7888.6 ± 3.180.7046970.4 ± 11.6465.1 ± 7.920.65633
IL21137.60 ± 16.3673.8 ± 8.090.00117166.4 ± 14.46129.9 ± 8.140.02706
IL4208.68 ± 202.2561.1 ± 39.250.48816457.8 ± 250.77105.7 ± 40.470.15920
IL23A1885.19 ± 212.502219.2 ± 194.680.258231825.8 ± 609.552373.5 ± 560.110.33497
IL531.23 ± 3.1841.0 ± 4.840.1329511.2 ± 5.046.5 ± 1.700.36160
IL6161.88 ± 119.041346.6 ± 675.510.1030016.9 ± 10.60507.6 ± 308.940.14098
IL2597.71 ± 3.54107.1 ± 6.220.2320180.4 ± 28.04184.5 ± 110.040.34049
IL27797.39 ± 131.93907.6 ± 115.360.576151405.0 ± 207.121492.6 ± 117.560.64230
IL31176.84 ± 50.04189.9 ± 31.480.82849692.8 ± 114.76641.7 ± 53.970.61297
TNF24.80 ± 4.17118.2 ± 42.260.0403638.5 ± 11.62187.6 ± 30.420.00053
LTA255.99 ± 22.00254.1 ± 16.760.94290137.0 ± 51.7998.8 ± 25.430.40572
IL28A427.57 ± 21.46438.4 ± 24.160.70711431.4 ± 42.59467.1 ± 35.380.49168
  • Abbreviations: CSF2 (GM-CSF, granulocyte-macrophage colony-stimulating factor); IFNG, interferon gamma; LTA, lymphotoxin alpha (TNF-beta).

  • aCytokine concentration (pg/mg tissue protein, mean ± standard error).