Table 1.

Characteristics of 368 women offered tamoxifen and 298 women who accepted

All women offered tamoxifenWomen accepting tamoxifen initiation
Declined (n = 71)Accepted (n = 298)PAdherent (n = 214)Nonadherent (n = 59)P
Median age (IQR)55 (50–68)60 (53–67)0.0560 (54–67)57 (52–68)0.09
Ancestrya
 Non-European27 (38.0%)87 (29.5%)0.3268 (32.2%)12 (20.3%)0.22
 European44 (62.0%)210 (70.5%)145 (67.8%)47 (79.7%)
Family history breast cancer
 No31 (43.7%)127 (42.6%)0.7587 (40.7%)26 (44.1%)0.70
 Yes35 (49.3%)140 (47.0%)104 (48.6%)28 (49.1%)
 Unknown5 (7.0%)31 (10.4%)23 (10.7%)4 (6.8%)
SES
 1st tertile21 (29.6%)78 (26.2%)0.5656 (26.2%)15 (25.5%)0.99
 2nd tertile30 (42.2%)115 (38.7%)84 (39.3%)19 (32.2%)
 3rd tertile20 (28.2%)104 (34.9%)73 (34.1%)25 (42.4%)
 Unknown0 (0.0%)1 (0.2%)0.331 (0.4%)0 (0.0%)0.28
Insurance status
 None13 (18.3%)44 (14.8%)0.6612 (5.6%)15 (25.4%)<0.01
 Private37 (52.1%)170 (57.0%)137 (64.0%)28 (47.5%)
 Government21 (29.6%)84 (28.2%)65 (30.4%)16 (27.1%)
DCIS sizeb
 Quantifiable
  Median mm (IQR)10.5 (3, 33)13 (5, 28)0.5915 (6, 30)7 (3, 14)<0.01
 Nonquantifiable
  No residual DCIS n (%)7 (9.9%)24 (8.0%)0.2318 (8.4%)4 (6.8%)0.88
  Extensive n (%)1 (1.4%)16 (5.4%)0.118 (3.7%)7 (11.9%)0.04
DCIS grade
 115 (21.1%)55 (18.5%)0.8537 (17.3%)15 (25.4%)0.46
 238 (53.5%)155 (52.0%)113 (52.8%)31 (52.6%)
 318 (25.4%)84 (28.2%)61 (28.5%)12 (20.3%)
 Unknown0 (0.0%)4 (1.3%)3 (1.4%)1 (1.7%)
Surgical therapy
 Breast conservation56 (78.9%)257 (86.2%)0.14185 (86.5%)48 (81.4%)0.40
 Unilateral mastectomy15 (21.1%)41 (13.8%)29 (13.5%)11 (18.6%)
Complete local therapyc
 No (BCS no RT)27 (38.0%)63 (21.4%)<0.0139 (18.2%)19 (32.2%)<0.01
 Yes (mastectomy or BCS with RT)44 (64.0%)232 (78.6%)174 (81.3%)38 (64.4%)
Radiotherapy (BCS only)c
 No27 (48.2%)63 (24.8%)<0.0139 (21.2%)19 (41.3%)<0.01
 Yes29 (51.8%)191 (75.2%)145 (78.8%)25 (58.7%)
Medical oncology referral for endocrine therapy
 No24 (33.8%)59 (19.8%)<0.0141 (19.2%)16 (27.1%)0.33
 Yes47 (66.2%)206 (69.1%)158 (73.8%)38 (64.4%)
 Unknown0 (0%)33 (11.1%)15 (7.0%)5 (8.5%)
New breast cancer event
 Ipsilateral11 (15.5%)17 (5.7%)0.0112 (5.6%)5 (8.5%)0.38
 Contralateral1 (1.4%)17 (5.7%)0.2212 (5.6%)4 (6.8%)0.76
Length of follow-up (months)
 Median (range)74.6 (55.9–93.6)81.7 (64.9–95.4)0.1285.0 (70.2–96.3)72.3 (59.5–94.9)0.01
  • Abbreviations: BCS, breast conservation surgery; IQR, interquartile range; RT, breast radiotherapy.

  • aOne woman with unknown ancestry was excluded.

  • bPatients with radiographic/pathologic evidence of extensive DCIS were not included in median size calculations.

  • cUse of radiotherapy unknown for 3 women.