Table 3.

The sRANKL/OPG ratio and breast cancer risk by hormone receptor subtype: EPIC nested case–control study

Quintiles
12345
Cut-off pointsa<0.0030.003–0.0080.008–0.0140.014–0.0226≥0.0226PtrendbRRlog2phetcphetd
Whole population
ER+/PR+
 Cases/controls146/177175/181186/178184/180224/199915/915
 RR (95% CI)Ref.1.17 (0.84–1.63)1.26 (0.90–1.76)1.21 (0.86–1.69)1.42 (1.01–1.98)0.211.04 (0.98–1.10)0.02
ER+
 Cases/controls296/328332/333311/318301/306350/3051,590/1,590
 RR (95% CI)Ref.1.13 (0.90–1.43)1.12 (0.88–1.42)1.10 (0.86–1.40)1.33 (1.03–1.71)0.121.03 (0.99–1.08)0.05
ER−/PR−
 Cases/controls45/4146/4253/4760/6046/60250/250
 RR (95% CI)Ref.1.10 (0.56–2.15)1.04 (0.55–1.98)0.86 (0.44–1.66)0.60 (0.31–1.14)0.030.88 (0.78–0.99)
ER−
 Cases/controls70/6670/6080/7679/8778/88377/377
 RR (95% CI)Ref.1.24 (0.73–2.09)0.93 (0.56–1.55)0.77 (0.46–1.31)0.74 (0.44–1.25)0.100.92 (0.84–1.01)
Age at diagnosis <50 years
ER+/PR+
 Cases/controls7/1020/2017/2528/1848/47120/120
 RR (95% CI)Ref.0.65 (0.16–2.74)0.36 (0.07–1.74)1.14 (0.29–4.51)0.94 (0.25–3.58)0.481.08 (0.87–1.35)
ER+
 Cases/controls11/1223/2421/2931/2456/53142/142
 RR (95% CI)Ref.0.58 (0.16–2.05)0.36 (0.10–1.36)0.79 (0.24–2.59)0.74 (0.23–2.41)0.671.04 (0.85–1.28)
Age at diagnosis ≥50 years
ER+/PR+
 Cases/controls139/167155/161169/153156/162176/152795/795
 RR (95% CI)Ref.1.18 (0.84–1.66)1.37 (0.97–1.94)1.13 (0.80–1.61)1.44 (1.00–2.06)0.251.04 (0.97–1.10)0.020.98
ER+
 Cases/controls285/316309/309290/289270/282294/2521,448/1,448
 RR (95% CI)Ref.1.14 (0.90–1.45)1.17 (0.91–1.51)1.06 (0.82–1.37)1.34 (1.03–1.75)0.141.03 (0.99–1.08)0.050.97
ER−/PR−
 Cases/controls44/3843/3847/4151/5531/44216/216
 RR (95% CI)Ref.1.13 (0.56–2.28)1.06 (0.53–2.10)0.78 (0.38–1.57)0.47 (0.23–0.98)0.030.87 (0.76–0.98)0.43
ER−
 Cases/controls67/6264/5568/6166/7553/65318/318
 RR (95% CI)Ref.1.22 (0.70–2.13)1.03 (0.60–1.78)0.74 (0.42–1.29)0.65 (0.37–1.15)0.100.92 (0.83–1.02)0.50
  • aCut-off points reflect non-log transformed sRANKL/OPG ratio values.

  • bPtrend based on log2-transformed sRANKL/OPG ratio.

  • cPheterogeneity comparing ER+/PR+ to ER−/PR− and ER+ to ER− subtypes, based on RRlog2.

  • dPheterogeneity comparing age at diagnosis <50 to ≥50 years based on RRlog2.

  • Conditional logistic regression models adjusted for: ages at menarche (<12, 13, 14, ≥15, missing), menopause (<44, 44–47, 48–50, 51–52, 53–54, ≥55, missing), and first full-term pregnancy (no FTP, <25, 25–30, ≥30, missing), and number of full-term pregnancies (0, 1, 2, ≥3, missing) and BMI (kg/m2, continuous).